5 EASY FACTS ABOUT PKRRATING DESCRIBED

The activated enzyme then phosphorylates its important substrate, the translational initiation variable eIF2α. The resulting translational arrest blocks viral replication. PKR belongs to the conserved spouse and children of 4 protein kinases (PKR, PERK, GCN2, HRI) that every one phosphorylate eIF2α in reaction to diverse stimuli12, triggering the